Here's that question

I'm the yin to Carlos' yang .....
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Well I wouldn't confront her but you could ask her if she's ok and tell her you've noticed she hasn't been her usual self...Ask her is everything ok at work? with friends? blah blah blah...Let her know you're there for her if there's anything bothering her but you don't like seeing her this way...If there's something she needs to get off her chest she'll hopefully take the opening, if she does in fact have something to say, LISTEN and HEAR what she has to say without jumping up in arms with the I KNEW IT...There'll be plenty of time for gloating on how good u vibe radar is...
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It's easy to jump to conclusions when suspicion sets in, so deal with it sooner than later, but try not to presume you've got it all figured out before she has a chance to say her piece or peace (as the case may be)...
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Angie..

I'm the yang to Angie's yin.....
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I'm going to give you a different take on this...I..think she feels that you don't love her or care enough about her to have attended the wedding with her. She's questioning whether you are the man for her. You may not realize this but women in serious r'ships think that going to friend's weddings with the their bf in tow is a big deal...They get to show off their own conquests to their friends and subtly impress upon their bf that they should make a move in that direction at some point...
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It could also be that many times once you've put a bit of distance between yourself and your SO, that it causes you to reevaluate the relationship as a whole. Meeting someone interesting can further precipitate..feelings of doubt and angst over their current r'ship. ..
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I wouldn't assume that she hooked up with someone, unless you have trust issues, but it is clear that she no longer feels as close to you as she did prior to the trip. Communication is key...Talk it out...
C..

I am going to agree with Angie...You should let her know she has seemed a bit different..but that you are here for her. If you come out and ask she may get upset, especially if she did nto do anything wrong...You shoudl not really jump to conclusions...Maybe she just had a bad time or got in a fight with her friend or something? I don't know though it is all up to you. Good luck with things!..

Would you prefer to know or not to know? If you really want to know, how is it going to affect you? Ask her again about the wedding, she could have been fairly hungover after the weekend she had and too tired to talk about it. If she still sounds sketchy then ask her outright. Prepare for her to be annoyed if nothing happened. She might of course lie.. It seems thatb you've already convinced yourself that something has happened, so you're better off putting your mind to rest or finding out for sure, so you can make the next decision...

Hmmm. A friend of mine went to her high school reunion and hooked up with a guy who lived across the country. And she didn't tell her boyfriend about the boy. She went across the country to visit the boy. And actually almost moved there. She did end up staying with the boyfriend (for a while) if it makes you feel any better...
Just ask her what's up. Ask her if something happened at the wedding that made her act differently toward you. Maybe she realized that she wants to get married and that she's wasting her time with you because you guys aren't going to get married. Or maybe she was more mad that you thought that you didn't go to the wedding with her. Acting sketch toward you doesn't mean she slept with someone else (although it doesn't say good things for your relationship that it's the first thing you thought of. Do you trust her at all?)..